Louisiana, Missouri to St. Louis, Missouri
Calhoun County to Granite City, Illinois

The following are sites are located in the Middle Mississippi Valley from Louisiana, Missouri to St. Louis, Missouri and Granite City Illinois. It points out locations such as the Clarksville, Missouri and Hardin, Illinois riverfronts, Lock and Dam # 25, The Two Rivers National Wildlife Refuge, the Brussels Free Ferry, Pere Marquette State Park, the Grafton riverfront. It also includes the Meeting of the Great Rivers National Scenic Byway, the Melvin Price Locks and Dam, and the Riverlands Environmental Demonstration Area.