Visitors Guide to
Motels & Other Lodging
in the Mississippi River Meets the Ohio River Region
of the Middle Mississippi River Valley
   
Americas Best Value Inn
1500 Liberty Street
Perryville, MO
573-547-1091
  The hometown pride and commitment by Americas Best Value Inn owners provide every guest with exceptional comfort, quality, and service at the most affordable rates. One visit and you will know why we are Americas Best Value Inn North America.
Americas Best Value Inn
700 E. Main Street
Carbondale, IL
618- 457-5566
  The hometown pride and commitment by Americas Best Value Inn owners provide every guest with exceptional comfort, quality, and service at the most affordable rates. One visit and you will know why we are Americas Best Value Inn North America.
Americas Best Value Inn
128 E. Walnut Street
Murphysboro, IL
618- 687-2244
  The hometown pride and commitment by Americas Best Value Inn owners provide every guest with exceptional comfort, quality, and service at the most affordable rates. One visit and you will know why we are Americas Best Value Inn North America.
Apple Tree Inn
200 N. 2nd Street
Murphysboro, IL
618-687-2345
  Apple Tree Inn warmly welcomes all visitors to the beautiful city of Murphysboro. We look forward to your visit and invite you to our inn. Apart from providing you with comfortable accommodations, we host community events, special functions, parties, family reunions & weddings.
Best Western Plus Saluki Inn
801 N. Giant City Road
Carbondale, IL
618-351-6611
  Whether visiting for business or for leisure, the Best Western Saluki Inn offers everything travelers need to rest and relax while on the road, including thoughtful touches in well-appointed rooms for a more comfortable stay, like cable or satellite television, a refrigerator, microwave, desk/work area and high-speed Internet access.
Budget Inn
221 S. Kingshighway Street
Perryville, MO
573-547-4516
  Budget Inn is economy motel chain that offers the best room rates, basic amenities, and basic rooms at affordable room rates.
Budget Inn
1448 N. Kingshighway Street
Cape Girardeau, MO
573-334-2828
  Budget Inn is economy motel chain that offers the best room rates, basic amenities, and basic rooms at affordable room rates.
Candlewood Suites
485 South Mt. Auburn Road
Cape Girardeau, MO
573-334-6868
  The spacious suites of Candlewood Suites in Cape Girardeau offer travelers room to work, relax, and offers convenient access to restaurants, shopping and the West Park business district. Located just off I-55, travelers love such amenities as a full kitchen, free wifi access, business center, indoor pool, and outdoor hot tub.
Coach House Inn & Suites
220 South Interstate Drive
Sikeston, MO
573-471-9700
  This hotel offers travelers large well-appointed suites and friendly service to amount to a home away from home. We are pet friendly. Enjoy the outdoor pool and exercise facility. Finally, guests are greeted each morning with a complimentary breakfast featuring make your own waffles as well as biscuits and sausage gravy.
Comfort Inn
1517 S. Perryville Blvd.
Perryville, MO
573-547-1727
  Guests will enjoy many amenities, including free local calls, free weekday newspaper and free coffee in the lobby. There is a seasonal outdoor pool and hot tub. In addition to standard amenities, all spacious guest rooms include refrigerators, coffee makers, free high-speed Internet access in all rooms and cable television with HBO.
Comfort Inn & Suites
109 Matthews Lane
Sikeston, MO
573-472-0197
  This hotel offers amenities and features like free wireless high-speed Internet access in all rooms, free local calls, and complimentary hot breakfast. All guest rooms come equipped with refrigerators, microwaves, coffee makers, curved shower rods, flat-screen televisions, voice mail, hair dryers, irons, ironing boards and cable television.
Days Inn
1330 S. Main Street
Sikeston, MO
573-471-3930
  Feel refreshed and energized when you stay at Days Inn. Value at this hotel helps you make the most of your travels. Get plenty of rest in one of our comfortable rooms, then awake to free Daybreak continental breakfast. Kids 17 and under stay free with an adult at our pet-friendly hotel.
Eagle Inn
2811 E. Marshall Street
Charleston, MO
573-683-3900
  We offer our guests exceptional, personalized service at this ideally located right off Interstate 57, the Eagle Inn Hotel is perfect for business and leisure travelers. Our hotel offers using a local gym, free Danishes and coffee in the morning, free wireless high-speed Internet access, free local calls, copy and fax services.
Econo Lodge
310 S. Story Street
Charleston, MO
573-683-2125
  Rise and shine every morning to a free hot continental breakfast and free coffee. Guests will enjoy additional amenities and features like free high-speed Internet access, free local calls, a seasonal outdoor pool and a picnic area. All standard guest rooms come equipped with microwaves, refrigerators and cable television with free HBO.
Econo Lodge Inn & Suites
801 E. Main Street
Carbondale, IL
618- 457-3347
  The Econo Lodge Inn & Suites hotel is one mile from Southern Illinois University Carbondale. This Illinois hotel offers features and amenities, including free continental breakfast, free wireless high-speed Internet access, free local calls, and an indoor heated pool.
Hampton Inn
103 Cape West Parkway
Cape Girardeau, MO
573-651-3000
  Relax in a comfortable guest room featuring a clean and fresh Hampton bedsŪ. Accessible rooms are designed with generous door and furniture clearances for easy movement. Stay connected with free high-speed internet access. Maintain your exercise routine in our fitness center. Start your day right with a Hampton free hot breakfast.
Hampton Inn
2175 N. Reed Station Road
Carbondale, IL
618- 549-6900
  Relax in a comfortable guest room featuring a clean and fresh Hampton bedsŪ. Accessible rooms are designed with generous door and furniture clearances for easy movement. Stay connected with free high-speed internet access. Maintain your exercise routine in our fitness center. Start your day right with a Hampton free hot breakfast.
Heritage Motel
1209 W. Main Street
Carbondale, IL
618- 457-4142
  The legendary Heritage Motel offers clean and quiet rooms at reasonable rates. Rooms at the Heritage are equipped with a fridge, microwave, free WiFi internet, and 75 channels of cable TV in every room, as well as an on-site laundry room. Deluxe rooms with kitchenettes and apartment suites are also available.
Holiday Inn Express
3253 William Street
Cape Girardeau, MO
573-334-4491
  We know it's the extra perks that make your stay unforgettable. We provide an indoor pool and fitness center to help you relax and unwind. Be sure to stop by our breakfast bar each morning, too, for biscuits, eggs, fruit and our signature cinnamon rolls. We look forward to your next visit!
Holiday Inn Express
120 S. Interstate Drive
Sikeston, MO
573-481-9500
 

Large, illuminating windows and contemporary decor welcome you to this Inn.

Connecting to colleagues and family is easy with the free high-speed, Wi-Fi access. Mornings start great with our free, hot Express Start breakfast bar. Go for a dip in the indoor pool or burn calories in our state-of-the-art fitness center.
Holiday Inn
2300 Reed Station Parkway
Carbondale, IL
618- 549-2600
  At the award-winning Holiday Inn Hotel & Conference Center, our hotel staff welcomes you to the "Capital of Southern Illinois" and home to Southern Illinois University Carbondale and assures your comfort is a top priority.
Motel 6
110 S. Interstate Drive
Sikeston, MO
573-471-7400
  This Motel 6 has been fully renovated. It offers large rooms with free high speed wireless internet access and a coin laundry facility. It also has a large area for parking semi-trucks and buses.
Quality Inn
102 Drake Street
Charleston, MO
573-683-4200
  Located in historic Charleston, Missouri, this Quality Inn offers a free hot breakfast, free high-speed Internet access in all rooms, lobby and breakfast area, free weekday newspaper, free local calls. There is also a seasonal outdoor pool free access to a local health club. This is a pet-friendly motel.
Super 8
1119 Vincent Drive
Perryville, MO
573-517-7888
  This Super 8 motel offers free Wi-Fi Internet access, a fitness room, a heated indoor pool and spa. All hotel rooms come with microwaves and refrigerators. Kids 17 and under stay free with an adult. Finish your stay with a free SuperStart continental breakfast, including hot items.
Super 8
2011 N, Kingshighway Street
Cape Girardeau, MO
573-339-0808
  Each room includes free Wi-Fi Internet access and refrigerator. The free parking lot has plenty of space for large vehicles. After a long stretch on the road, swim in our outdoor pool or book one of our Jacuzzi suites to unwind. In the morning help yourself to free SuperStart continental breakfast.
Super 8
1180 E. Main Street
Carbondale, IL
618- 457-8822
  Rely on motel hotel to provide value when you stop in from the road. Our comfortable, non-smoking rooms and suites are equipped with free Wi-Fi Internet access, microwaves, and refrigerators. Handicapped-accessible accommodations are available. In the morning, enjoy free SuperStart continental breakfast. We offer free parking for your truck, bus or RV.
Super 8
2609 E. Malone Avenue
Sikeston, MO
573-471-7944
  Use the free Wi-Fi Internet or log on to high-speed Internet in our business center. Our comfortable rooms help you get the rest you need, and free SuperStart continental breakfast awaits you each morning. Large-vehicle parking spaces with outdoor electrical outlets for truck, bus, or RVs. Handicapped-accessible and non-smoking rooms are available.
Quality Inn
1415 E. Main Street
Carbondale, IL
618-549-4244
  Guests of this motel will enjoy free continental breakfast with hot items, free wired and wireless high-speed internet access, free local calls and free unlimited long distance calls within the United States, free newspaper, and an indoor heated pool and fitness center.
Campus Inn
Carbondale, IL
  1345 E. Main Street
1-800-237-8466
Drury Lodge
Cape Girardeau, MO
  104 S. Vantage Drive
573-334-7151
Drury Inn & Suites
Sikeston, MO
  2608 E. Malone Avenue
573-472-2299
Pear Tree Inn
Sikeston, MO
  2602 E. Malone Avenue
573-471-4100
Wickliffe Motel
Wickliffe, KY
  520 4th Street
270-335-3121
   
If you operate a business in the area and do not find your business listed, please visit our contact us page for information on free listings with a 50 word description or and other inexpensive advertising options. greatriverroad.com appreciates readers that know of a business that has closed and visits our contact us page and lets us know so that we can update our directory.
   






 
 
FEATURED ATTRACTIONS ALONG THE GREAT RIVER ROAD
Saxon
Lutheran Memorial
Columbus-Belmont
State Park
General John A. Logan
Museum
Sikeston Depot
Cultural Center
     
 
 
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